Swansea Baby Trial
Probiotics in the prevention of eczema: a randomized controlled trial
- The study was carried out at Swansea University Medical School.
- 454 mother/baby pairs took part in the trial.
- Group 1: The mothers took daily a placebo during the last month of pregnancy and then gave the same preparation to their newborn babies every day for 6 months following birth.
- Group 2: The mothers took 10 billion of the Lab4b probiotic per day during the last month of pregnancy and then gave the same probiotic to their newborn babies every day for 6 months following birth.
- Skin prick tests were carried out on both the Lab4b probiotic and placebo infant groups to detect allergic reaction to the most common allergens, including cow’s milk, egg, house dust mite and pollen.
- Atopic eczema was defined as eczema with one or more positive SPT’s
- The babies given the Lab4b probiotics were 57% less likely to develop atopic eczema than those receiving the placebo (*P<0.05).
- The babies given Lab4b were 44% less likely to develop allergic reaction to common allergens, including pollen, cow’s milk, egg and house dust mite (*P<0.05) .
Atopic eczema – Infants (%)
Atopic sensitization – SPT Positive (%)
The primary author, Prof. Steve Allen, concluded the following key message from the trial: ‘Lactobacilli and Bifidobacteria administered to pregnant women and infants aged 0-6 months prevented atopic sensitization and atopic eczema.’