Enteric inflammation reduced through supplementation

This study carried out an assessment of the intestinal microbiome composition and the pre-term infant’s response to these colonizing bacteria. Infants born <32 weeks gestational age were fed B. infantis EVC001 8 × 109 CFU in MCT oil up until 34 weeks gestational age. Faecal samples from 77 premature infants were taken throughout 26–40 weeks and taxonomic profiling of the metagenomic samples was performed.

In conclusion, they found that (1) increased human milk utilization; (2) diminished enteric inflammation; and (3) decreased the abundance of taxa associated with antibiotic-resistance and poor health outcomes. Together with human milk feeding, B. infantis EVC001 can mitigate microbiome-associated risk of morbidity and mortality in hospitalized infants.

Nguyen M et al, Impact of Probiotic B. infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation. Frontiers in Pediatrics :V9, 2021, https://www.frontiersin.org/article/10.3389/fped.2021.618009, DOI=10.3389/fped.2021.618009   

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