Probiotic administration enhances expression of tight junction proteins

5 Lactobacillus and 5 Enterococcus strains isolated from infant gut microbiome were administered in this study to ageing mice. Bacterial genomic DNA was isolated from collected faeces and analysed alongside metabolites of gut bacteria. This study comprehensively demonstrates how a probiotic therapy modulates gut microbiota to enhance the abundance of beneficial metabolites like taurine, which reduces leaky gut and improves a healthy life span. This study concluded that a human origin probiotic therapy prevented metabolic dysfunctions — namely glucose intolerance, insulin resistance, hepatic steatosis, and fat tissue inflammation, in older mice.  Further human studies may provide ground breaking treatment for thousands of people nationwide.

Shokouh Ahmadi et al. A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis. JCI Insight 2020;5(9):e132055.

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