The living environment of young children can enhance immune function
75 children between 3-5 years attending 10 daycare centres across Finland were included in this 28-day study. Three daycare centres were standard urban non-green spaces. Four were standard urban non-green spaces that were modified with gravel, shrubs, soil and sand. The remaining three were left untouched as the control daycare centres.
Specifically, the intervention was associated with a shift toward a higher ratio between plasma cytokine IL-10 and IL-17A levels and a positive association between Gammaproteobacterial diversity and Treg cell frequencies in blood, suggesting that the intervention may have stimulated immunoregulatory pathways.
The ADELE research group: Mira Grönroos, Olli H. Laitinen, Raul Kalvo, Iida Mäkelä, Hui Nan, Noora Nurminen, Sami Oikarinen, Anirudra Parajuli, Riikka Puhakka, Marja I. Roslund, Mika Saarenpää, Laura Soininen, Heli K. Vari, Guoyong Yan, Juho Rajaniemi, Heikki Hyöty, Aki Sinkkonen Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Science Advances 14 Oct 2020: Vol. 6, no. 42, eaba2578 DOI: 10.1126/sciadv.aba2578
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