Nicotine free vapour causes increased gut permeability

Mice models of acute and chronic e-cigarette aerosol inhalation, mouse colon transcriptomics and mouse and human gut derived organoids in co-culture models, were assessed for the effects of e-cigarette use on the gut barrier. Results showed that e-cigarettes disrupt the integrity of the gut epithelial barrier. Acute exposure to e-cigarettes did not have an effect on the colon but chronic exposure over 3 months showed significant changes in gene expression. Such disruption is associated with the induction of pro-inflammatory cytokines and a failure to induce protective reactive oxygen species (ROS). Furthermore, colons of mice exposed to nicotine-free, but not nicotine-containing e-cigarettes have impaired tight junction markers and are inflamed.

Sharma, A., Lee, J., Fonseca, A.G., Moshensky, A., Kothari, T., Sayed, I.M., Ibeawuchi, S.-R., Pranadinata, R.F., Ear, J., Sahoo, D., Crotty-Alexander, L.E., Ghosh, P., Das, S., E-cigarettes compromise the gut barrier and trigger inflammation, ISCIENCE (2021),

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