Gluten not impactful in IBS
This study measured markers of epithelial injury (syndecan-1) including bacterial translocation from 82 IBS sufferers. All participants were administered a low FODMAP diet. One group was administered a gluten‐free diet, during blinded challenges with gluten or a placebo. Results found that colonic epithelial injury is reduced when gluten and low FODMAP diets are observed simultaneously, whilst a gluten free diet alone did not reduce such markers. This implicates FODMAPs in epithelial injury in IBS.
Ajamian, M., Rosella, G., Newnham, E. D., Biesiekierski, J. R., Muir, J. G., Gibson, P. R., Effect of Gluten Ingestion and FODMAP Restriction on Intestinal Epithelial Integrity in Patients with Irritable Bowel Syndrome and Self‐Reported Non‐Coeliac Gluten Sensitivity. Mol. Nutr. Food Res. 2020, 1901275. https://doi.org/10.1002/mnfr.201901275
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