Blood metabolites in late adulthood indicate health status
This study analysed three independent cohorts comprising over 9,000 individuals to find an increasing compositional uniqueness of the gut microbiome, as a component of healthy ageing. Characteristics of which are highlighted by distinct microbial metabolic outputs in the blood. Furthermore, this study highlights the fact that the adult gut microbiome continues to develop with advanced age in healthy individuals, but not in unhealthy ones, and that microbiome compositions associated with health in early-to-mid adulthood may not be compatible with health in late adulthood.
Wilmanski, T., Diener, C., Rappaport, N. et al. Gut microbiome pattern reflects healthy ageing and predicts survival in humans. Nat Metab 3, 274–286 (2021). https://doi.org/10.1038/s42255-021-00348-0
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