This cross-sectional study was carried out in the UK and Switzerland to isolate the genetic influence on Rheumatoid Arthritis. The results highlight a link between genetic risk for rheumatoid arthritis and the gut microbiota. An increase in abundance of Prevotella_7. Genotype might mediate key taxonomic associations of the gut microbiota with rheumatoid arthritis, particularly Prevotella spp, suggesting that these species play a role in the early development of rheumatoid arthritis.
Philippa M Wells, Adewale S Adebayo,Ruth C E Bowyer, Maxim B Freidin, Prof Axel Finckh, Till Strowig, Till Robin Lesker, Deshire Alpizar-Rodriguez, Benoit Gilbert, Bruce Kirkham, Prof Andrew P Cope, Claire J Steves, Prof Frances M K Williams July 2020. Associations between gut microbiota and genetic risk for rheumatoid arthritis in the absence of disease: a cross-sectional study. The Lancet Rheumatology DOI:https://doi.org/10.1016/S2665-9913(20)30064-3
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