Metabolites contribute to diabetes progression

1958 subjects from the MetaCardis cohort were reviewed for blood glucose, nutritional and metagenomic analysis. It was found that imidazole propionate levels were increased in subjects with low bacterial gene richness. They concluded that metabolites, such as Imidazole propionate (ImP), may provide a more relevant indicator of an altered microbial function across populations than metagenomic sequencing. They observed that an unhealthy diet, but not histidine intake, was associated with increased ImP levels.

Since ImP has been observed to be increased in subjects with glucose intolerance and type 2 diabetes of several origins, personalized dietary recommendation might be helpful for reducing circulating ImP levels.

Molinaro, A., Bel Lassen, P., Henricsson, M. et al. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nat Commun 11, 5881 (2020).

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