Bacteria and their metabolites differ in healthy and food-allergic twins
This study collected faecal samples from a unique, well-controlled cohort of 18 twin pairs concordant or discordant for food allergy. An integrated microbial and metabolomic analysis of human faecal samples from allergic and healthy twins was performed and identified differentially abundant bacteria and metabolic compounds as well as pathways between the 2 groups. A microbiota abundance score dominated by bacteria with greater abundance in healthy twins, correlated positively with distinct metabolite pathways to identify P. faecium and R. bromii as significantly enriched in the healthy twins. This study demonstrates that the gut microbiota may play a protective role in patients with food allergies beyond the infant stage and through adulthood.
Fecal microbiome and metabolome differ in healthy and food-allergic twins. Riyue Bao, Lauren A. Hesser, Ziyuan He, Xiaoying Zhou, Kari C. Nadeau, and Cathryn R. Nagler. J Clin Invest. 2021;131(2): e141935. https://doi.org/10.1172/JCI141935
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