Synbiotic effects of pre-& probiotics analysed

In a double-blind, randomized controlled clinical trial of 28 days, children aged 14 to 60 months with Cerebral Palsy (CP), were found to have improved stool characteristics. Chronic constipation was improved in those taking the probiotic strain of L. reuteri DSM 17938. Intestinal motility and lower pH of stool samples was also found in the trial group. The Agave source of inulin, when administered alone, resulted in improved stool consistency. Interestingly, when combined as a synbiotic treatment, the subjects ‘did not show the same effect’. More research is required into the most optimal substrate for L. reuteri and lactic acid bacteria over a longer trial period but results here are encouraging.


Contreras, A.A.G.; Garibay, E.M.V.; Ramírez, C.A.S.; Fafutis Morris, M.; Delgado Rizo, V. Lactobacillus reuteri DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial. Nutrients 2020, 12, 2971.

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