This study investigated whether Lactobacillus reuteri induced AhR ligand production by the gut microbiota could influence gluten immunopathology. Patients with active celiac disease demonstrated reduced AhR ligand production and lower intestinal AhR pathway activation. These results highlight gut microbiota-dependent modulation of the AhR pathway in coeliac disease and suggest a new therapeutic strategy for treating this disorder.
Bruno Lamas et al Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation. Science Translational Medicine 21 Oct 2020: Vol. 12, Issue 566, eaba0624 DOI: 10.1126/scitranslmed.aba0624
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