Protective role of intestinal microbial detoxification

39 Children with Autism Spectrum Disorder (ASD) and 40 controls, all aged 3-8 years were the subjects of this study in Peking. For analysis based on quasi-paired cohort strategy, a further 65 ASD-control pairs, including 20 ASD subjects and 18 control subjects from the original group. Faecal and urine samples were taken for microbial and metagenome analysis. Via a quasi-paired cohort, they identified a trend of impaired microbial detoxification in the gut of ASD subjects and that this was strongly correlated to the clinical rating of ASD. The potentially protective role of intestinal microbial detoxification against the development of ASD is ground-breaking. The quasi-paired cohort is also an asset of this study, powerfully identifying disease-associated microbial features, here and in future research.

Mengxiang Zhang et al. A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children. Science Advances 21 Oct 2020: Vol. 6, no. 43, eaba3760 DOI: 10.1126/sciadv.aba3760

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