Bacterial influence on chemotherapy treatment
This study dissects a four-way interaction between the amino acid serine (diet), the chemotherapeutic 5′-fluorodeoxyuridine (drug), the bacterium E. coli (microbiota), and the roundworm C. elegans (host). It shows that dietary thymidine and serine enhance 5-fluoro 2′deoxyuridine (FUdR) toxicity in C. elegans through different microbial mechanisms. This offers enormous potential of developing drugs that can improve treatment outcomes by modulating the microbes that live in our gut.
Wenfan Ke, James A. Saba, Cong-Hui Yao, Michael A. Hilzendeger, Anna Drangowska-Way, Chintan Joshi, Vinod K. Mony, Shawna B. Benjamin, Sisi Zhang, Jason Locasale, Gary J. Patti, Nathan Lewis, Eyleen J. O’Rourke. Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-16220-w
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