Get 33% Off Our Royal Products 👑

*Excludes existing offers & subscriptions. Discount applied automatically within the checkout. Available from the 6th to 8th May 2023 

Login
Shop

☃️ Christmas Orders 🎁

Last orders for dispatch before Xmas will be Wednesday 21st December. 🎅 All orders after this date will be fulfilled from the 4th of January 2023. In the meantime, we wish you a merry Christmas 🎄 and a happy New Year ✨

3 for 2 Mix & Match Offer

*Cheapest item for free is applied automatically within the checkout. Available til the end of Jan 2023
**Excludes existing offers,  discounts & subscriptions.

20% Off Sale Women’s Probiotics

💘 Available from the 8th March to the 19th March on our three most popular women’s probiotics. 💘
💗 Discount added automatically at checkout for you. 💗

Cambridge Probiotic & Antibiotic Trial 1

Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebo-controlled pilot study.

Aim

This randomised, double blind, placebo-controlled study investigated the effect of Lab4 probiotic supplementation on the gut microbiota composition and prevention of pathogenic microorganisms overgrowth in response to antibiotic therapy.

Method

  • The study was carried out at Addenbrooke’s Hospital in Cambridge.
  • 22 patients requiring antibiotic therapy were divided into three groups
  • Stool analysis was then conducted over a 28-day period to assess the different populations of bacteria in the gut microbiota.
    • The Cambridge Probiotic / Antibiotic Trial 1 - ProVen Probiotics

    Results

    1. Total numbers of facultative anaerobes:

  • significantly increased in the patients on antibiotics and placebo at the end of the antibiotic treatment (*P<0.05) and remained increased post antibiotic therapy (*P<0.05) (Group 1)
  • significantly increased in the patients on antibiotics and placebo at the end of the antibiotic treatment (*P<0.05), but the numbers decreased significantly after introducing Lab4 probiotic supplementation post antibiotic (*P<0.05 when compared to day 7) (Group 2)
  • remained stable in the patients on antibiotics and Lab4 probiotics throughout the study period (Group 3)

    • 2. Lab4 probiotic supplementation reduced the overgrowth population of coliforms, enterococci and staphylococci in the re-growth microbiota following antibiotic therapy.

    Total number of ‘undesirable’ facultative anaerobes

    Post antibiotic therapy: Total number of faecal coliforms, enterococci and staphylococci (%)

    The Cambridge Probiotic / Antibiotics Trial 1 - ProVen Probiotics
    The Cambridge Probiotic / Antibiotics Trial 1 - ProVen Probiotics

    Conclusion

    The supplementation of Lab4 probiotics alongside antibiotic therapy has been shown to reduce the overgrowth of undesirable and potentially harmful bacteria both during and following antibiotic therapy.

    Reference

    Madden JAJ et al 2005. Effects of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebo-controlled pilot study.
    Int Immunopharmacology 5:1091-1097​

    Shop
    Why ProVen
    Resources

    † THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

    Scroll to Top