The Adult Immune Response Study
Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals
Aim
This study examined the effect of a 12-week Lab4 probiotic and fructooligosaccharide supplementation on ex-vivo pro-inflammatory and anti-inflammatory cytokine production by peripheral blood mononuclear cells extracted from healthy volunteers.
Method
Results
Fold change in TGF-β level
In the ‘resting’ immune state during challenge with bacterial toxin: :
- Significant decrease in production of the pro-inflammatory cytokines IL-6 and IL-1β(*P<0.01,**P<0.0001)
Fold change in IL-6 level