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ProChild-2 Study

Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomized controlled trial

Aim

This randomised, double-blind, placebo-controlled study assessed the impact of the Lab4 probiotic with low dose of vitamin C combination on the prevention of upper respiratory tract infection (URTI) symptoms and absenteeism in children aged 3 to 10 years.

Method

• 171 children aged 3-10 years were divided into two groups. • Group 1 received a placebo chewable tablet daily for 6 months • Group 2 received a chewable tablet containing the 12.5 billion Lab4 probiotics plus 50 mg Vitamin C daily for 6 months. • The incidence of URTI symptoms, absence from school, paediatric physician’s visits and antibiotic usage were recorded daily for 6 months.

Results

URTI symptoms

• 16% significant reduction in the incidence of coughing in Group 2 compared to Group 1 (Fig 1, *P<0.05).
• 20% significant reduction in the incidence of sore throats in Group 2 compared to Group 1 (Fig 1, *P<0.05).
• Only 5.8% children in Group 2 had all five URTI symptoms on one day compared to 18.8% children in Group 1 (P<0.05). URTI symptoms included cough, sore throat, sneezing, runny/blocked nose.
• 79% significant reduction in the incidence of episodes with all five URTI symptoms on one day (Fig 2, *P<0.0001)

Fig 1 Incidence of URTI symptoms

Fig 2 Incidence of all five URTI symptoms on one day

Proven-pro-Pro-child-2-graph-6-copy

Absenteeism

  • 16% significant reduction in the incidence of absenteeism from preschool/school in Group 2 compared to Group 1 (Fig 3, *P<0.05).
  • Fig 3 Incidence of absence from school

    Paediatric physician’s visit and antibiotic usage

    • Over the 6-month study period, the number of visits to the G.P for any reason was significantly reduced by 19% (Fig 4, *P<0.05)
    • Significant reduction in antibiotic use by 27% in Group 2 compared to Group 1 (Fig 4, *P<0.05).

    Fig 4 Incidence of GP visits and antibiotic usage

    Improvement in intestinal health

    • Significant improvement in the ‘normal’ stool consistency in Group 2 compared to Group 1 (Fig 5, *P<0.0001).
    • Significant reduction in the incidence of watery and hard stools episodes in Group 2 (Fig 5, *P<0.0001).

    Fig 5 Incidence of stool consistency  

    Conclusion

    Lab4 probiotics in combination with low dose of vitamin C reduce the incidence of coughing, sore throats together with absence from school and antibiotic use.
    To our knowledge, this is the first time two probiotic studies (ProChild and ProChild-2) with the same intervention for same duration showed the beneficial effect in the management of URTIs in children attending school.

    Reference

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