ProChild-2 Study
Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomized controlled trial
Aim
Method
Results
URTI symptoms
• 16% significant reduction in the incidence of coughing in Group 2 compared to Group 1 (Fig 1, *P<0.05).
• 20% significant reduction in the incidence of sore throats in Group 2 compared to Group 1 (Fig 1, *P<0.05).
• Only 5.8% children in Group 2 had all five URTI symptoms on one day compared to 18.8% children in Group 1 (P<0.05). URTI symptoms included cough, sore throat, sneezing, runny/blocked nose.
• 79% significant reduction in the incidence of episodes with all five URTI symptoms on one day (Fig 2, *P<0.0001)
Fig 1 Incidence of URTI symptoms
Fig 2 Incidence of all five URTI symptoms on one day
Absenteeism
Fig 3 Incidence of absence from school
Paediatric physician’s visit and antibiotic usage
- Over the 6-month study period, the number of visits to the G.P for any reason was significantly reduced by 19% (Fig 4, *P<0.05)
- Significant reduction in antibiotic use by 27% in Group 2 compared to Group 1 (Fig 4, *P<0.05).
Fig 4 Incidence of GP visits and antibiotic usage
Improvement in intestinal health
- Significant improvement in the ‘normal’ stool consistency in Group 2 compared to Group 1 (Fig 5, *P<0.0001).
- Significant reduction in the incidence of watery and hard stools episodes in Group 2 (Fig 5, *P<0.0001).
Fig 5 Incidence of stool consistency
Conclusion
Lab4 probiotics in combination with low dose of vitamin C reduce the incidence of coughing, sore throats together with absence from school and antibiotic use.
To our knowledge, this is the first time two probiotic studies (ProChild and ProChild-2) with the same intervention for same duration showed the beneficial effect in the management of URTIs in children attending school.