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The PROMAGEN Study Part 2: Overall Wellbeing

A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being

Aim

This randomised, double-blind, placebo controlled study aimed to assess the effect of 6-months supplementation with the Lab4P probiotic on body weight, plasma cholesterol and well-being in healthy overweight and obese individuals.

Method

  • The study was carried out in Sofia, Bulgaria.
  • 220 overweight and obese adults aged 30-65 (BMI 25-34.9, waist circumference >89cm for women or >100cm for men) were divided into two groups.
  • Group 1 took one placebo capsule daily for 6 months.
  • Group 2 received one capsule of 50 billion Lab4P probiotics (Lab4 consortium plus Lactobacillus plantarum CUL66) daily for 6 months.
  • The participants were asked to maintain their normal diet and lifestyle throughout the study.
  • Changes in body weight, BMI, waist circumference, cholesterol, incidence of upper respiratory tract infections (URTI) and self-perceived quality of life from the start of the study to 6 months were assessed.

Results

Total URTI symptoms
  • Significant 40% reduction in the incidence of total URTI symptoms in Group 2 compared to Group 1 (****P<0001). The URTI symptoms were defined as sneezing, cough, sore throat, runny nose and blocked nose).

Fig 1. The incidence rate of Total URTI Symptoms

The Promagen study - ProVen Probiotics
The Promagen study - ProVen Probiotics
Headaches
  • 32% significant reduction in the incidence of headache in Group 2 compared to Group 1 (****P<0001).

Fig 2. The incidence rate of Headache

The Promagen study - ProVen Probiotics
The Promagen study - ProVen Probiotics
Quality of Life assessment at 3 months
  • 3% significant improvement in General Wellness scores at 3 months (**P< 0.01) and 5.6% at 6 months (*P< 0.05) in the group supplemented with Lab4P probiotics (Group 2) compared to the placebo (Group 1).
  • Significant improvements in scores of State of Health (5.8%, *P<05), State of Energy (5.5%, *P< 0.05) and State of Mood (5.1%,*P< 0.05) were observed at 3 months (Figure 4).

Fig 3. Quality of Life

The Promagen study - ProVen Probiotics
The Promagen study - ProVen Probiotics

Conclusion

Supplementation of overweight and obese adults with the Lab4P probiotic for 6 months resulted in a significant reduction in the incidence of URTI symptoms and headache. The reported Quality of Life scores improved in response to the probiotic.

Reference

Michael DR et al. 2020
A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being.
Scientific Reports 10(1): 4183

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